Season 11 in Diablo 4 is flipping the usual endgame grind on its head with a new system called Sanctification. If you’ve been farming high-tier content and hitting that frustrating plateau, this is the fresh twist you’ve been waiting for. At the heart of it all are Sacred Affixes – not just boring stat bumps, but powers that can totally change how a skill performs or even how your whole build plays. We’re talking big, game-defining changes here. And yeah, chasing these is going to be just as addictive as hunting for Diablo 4 Items.

Here’s how it rolls. You can sanctify your top Ancestral Legendary or Unique, but you’ll need a new rare material – let’s call them Angelic Fragments – which drop from a seasonal endgame activity linked to the theme. Once you’ve farmed enough, you’ll head to the Sanctification Altar. The whole thing costs a lot, so this isn’t something you mess around with on throwaway gear. When you sanctify, the item will get a Sacred Affix from a pool tied to its slot. The kicker? Only one Sanctified item can be equipped at a time, so picking that slot becomes a major strategic call for your build.

The real jaw-dropper is the Sacred Affixes themselves. Picture your Barbarian’s Whirlwind suddenly pulling far-off enemies in and bleeding them out. Or your Sorcerer’s Fireball randomly bursting into Chain Lightning and frying everything nearby. For Rogues, maybe Twisting Blades sends back a path lined with Stun Grenades. These are the sort of effects that make you rethink your whole skill layout. You’ll start seeing old skills you never touched suddenly become core to a killer build because of one insane affix.

If you’re diving into this, slow down. A lot of folks waste fragments on gear that’s just “good enough” and then regret it. Wait until you’ve got a near-perfect base item – the kind with three or four affixes you already love – before you even think of sanctifying it. Meanwhile, grind that seasonal activity and pile up Angelic Fragments.

This is all about planning ahead and knowing exactly what kind of power spike your build needs. Make the right call and your setup can go from strong to ridiculous – and with the boost, those late-game bosses will feel a lot less scary, especially once you’ve got the stash and maybe even some extra diablo 4 gold for sale.